Trichloroethylene Ototoxicity: Evidence for a Cochlear Origin

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Trichloroethylene ototoxicity: evidence for a cochlear origin.

Trichloroethylene (TCE) is known to produce an unusual pattern of hearing impairment in laboratory animals marked by a preferential loss of threshold sensitivity at midfrequencies. The purpose of this research was to determine whether the TCE-induced auditory deficit results from cochlear dysfunction. Adult Long Evans hooded rats were exposed via inhalation to either 0 (clean air) or 4000 ppm T...

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Trichloroethylene and cancer: epidemiologic evidence.

Trichloroethylene is an organic chemical that has been used in dry cleaning, for metal degreasing, and as a solvent for oils and resins. It has been shown to cause liver and kidney cancer in experimental animals. This article reviews over 80 published papers and letters on the cancer epidemiology of people exposed to trichloroethylene. Evidence of excess cancer incidence among occupational coho...

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ژورنال

عنوان ژورنال: Toxicological Sciences

سال: 1998

ISSN: 1096-6080,1096-0929

DOI: 10.1093/toxsci/42.1.28